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Article

The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux.

Journal of lipid research - 1 Nov 2006

Gaidukov Leonid, Rosenblat Mira, Aviram Michael, Tawfik Dan S

Abstract excerpt

Serum paraoxonase (PON1) is a HDL-associated enzyme exhibiting potentially antiatherogenic properties. Here, we examined the common PON1-192R/Q human polymorphism. Despite numerous studies, the effect of this polymorphism on the antiatherogenic potential of PON1 is yet unresolved. Our structural...

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Source

Identifiers

PMID: 16914770
DOI: 10.1194/jlr.M600297-JLR200

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16914770-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux.PMID 16914770Read ↗

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Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification.Semantic proximity Read ↗

The paraoxonase-1 codon 192 polymorphism is associated with fasting total cholesterol and LDL-cholesterol concentrations only in postmenopausal women. The REGICOR study.Semantic proximity Read ↗

Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population.Semantic proximity Read ↗

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