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Article

The Arg allele in position 192 of PON1 is associated with carotid atherosclerosis in subjects with elevated HDLs.

Atherosclerosis - 1 Oct 2002

Gnasso Agostino, Motti Corradino, Irace Concetta, Di Gennaro Immacolata, Pujia Arturo, Leto Elio, Ciamei Monica, Crivaro Andrea, Bernardini Sergio, Federici Giorgio, Cortese Claudio

Abstract excerpt

Human serum paraoxonase (PON1) is an HDL-associated enzyme involved in the protection of lipoproteins from oxidation. A polymorphism at position 192 (Gln/Arg) influences its activity in a substrate-dependent manner. The aim of the present study was to evaluate, in vivo, the contribution of the PON1-192 polymorphism to the protective effect of HDLs. Three hundred and forty seven subjects in the upper and lower...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12204800
DOI: 10.1016/s0021-9150(02)00070-9

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Arg allele in position 192 of PON1 is associated with carotid atherosclerosis in subjects with elevated HDLs.PMID 12204800Read ↗

Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population.Semantic proximity Read ↗

p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample.Semantic proximity Read ↗

Paraoxonase1-192 polymorphism modulates the nonfatal myocardial infarction risk associated with decreased HDLs.Semantic proximity Read ↗

The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux.Semantic proximity Read ↗

The influence of PON1 192 polymorphism on endothelial function in diabetic subjects with or without hypertension.Semantic proximity Read ↗

Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.Semantic proximity Read ↗

Genetic and environmental determinants of the PON-1 phenotype.Semantic proximity Read ↗

Indications that paraoxonase-1 contributes to plasma high density lipoprotein levels in familial hypercholesterolemia.Semantic proximity Read ↗

The paraoxonase-1 codon 192 polymorphism is associated with fasting total cholesterol and LDL-cholesterol concentrations only in postmenopausal women. The REGICOR study.Semantic proximity Read ↗

Effect of the human serum paraoxonase 55 and 192 genetic polymorphisms on the protection by high density lipoprotein against low density lipoprotein oxidative modification.Semantic proximity Read ↗

Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults.Semantic proximity Read ↗

The gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in italian patients.Semantic proximity Read ↗

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