Article
The paraoxonase-1 codon 192 polymorphism is associated with fasting total cholesterol and LDL-cholesterol concentrations only in postmenopausal women. The REGICOR study.
Clinical chemistry and laboratory medicine - 1 Jul 2002
Senti Mariano, Tomás Marta, Elosual Roberto, Sala Joan, Masiá Rafel, Marrugat Jaume
Abstract excerpt
Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-linked enzyme which appears to protect low-density lipoproteins (LDL) from oxidation. PON1 activity is associated with variation at the PON1 gene locus, specifically the common amino acid polymorphism at codon 192, for which the Q192 allele specifies low activity and the R192 allele specifies high activity. We investigated the association between the PON1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.