Article
The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects.
Molecular and cellular biochemistry - 1 Aug 2013
Hassan Mohammed A, Al-Attas Omar S, Hussain Tajamul, Al-Daghri Nasser M, Alokail Majed S, Mohammed Abdul K, Vinodson Benjamin
Abstract excerpt
Paraoxonase-1 (PON1) is a HDL-bound antioxidant enzyme that protects LDL from oxidative modification. Discovery of the antioxidant properties of PON1 led to extensive research on its role in the initiation and progression of atherosclerosis. The Q192R (rs662; A/G) polymorphism, which results in the glutamine to arginine substitution at position 192, of the PON1 gene has been linked to increased atherosclerosis...
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