Article
PON1 is a longevity gene: results of a meta-analysis.
Ageing research reviews - 1 Oct 2009
Lescai Francesco, Marchegiani Francesca, Franceschi Claudio
Abstract excerpt
Paraoxonase 1 (PON1) is one of the most studied genes regarding cardiovascular risk, oxidative stress and inflammation. Several lines of evidence suggests that PON1 promotes an atheroprotective effect. Patients carrying PON1 codon 192 QQ genotype display a higher risk of cardiovascular events, the major cause of mortality in the elderly: it can be predicted that gene variants increasing the risk of mortality will...
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