Article
5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women.
The American journal of clinical nutrition - 1 Feb 2002
Fohr Iris P, Prinz-Langenohl Reinhild, Brönstrup Anja, Bohlmann Anja M, Nau Heinz, Berthold Heiner K, Pietrzik Klaus
Abstract excerpt
BACKGROUND: Elevated plasma total homocysteine (tHcy) is a risk factor for vascular disease and neural tube defects. The polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (FADH(2)) (MTHFR) influences the tHcy concentration and the response to tHcy-lowering therapy. Supplementation with folic acid (FA) decreases plasma tHcy, but limited data are available on the effect of...
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