Article
Optimization of dietary folate or low-dose folic acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype.
Journal of the American College of Cardiology - 1 Dec 2001
Pullin C H, Ashfield-Watt P A, Burr M L, Clark Z E, Lewis M J, Moat S J, Newcombe R G, Powers H J, Whiting J M, McDowell I F
Abstract excerpt
OBJECTIVES: We sought to study the effect of low-dose folic acid supplementation or optimization of dietary folate intake on plasma homocysteine and endothelial function in healthy adults. BACKGROUND: Elevated homocysteine is associated with cardiovascular disease, but it is not known whether this relationship is causal. Individuals homozygous (TT) for the C677T mutation in the methylenetetrahydrofolate reductase...
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