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Article

Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?

Kidney international - 1 Jul 2002

Andersen Steen, Tarnow Lise, Cambien Francois, Rossing Peter, Juhl Tina R, Deinum Jaap, Parving Hans-Henrik

Abstract excerpt

BACKGROUND: The beneficial short- and long-term renoprotective effects of angiotensin I-converting enzyme (ACE) inhibition are lower in albuminuric diabetic patients homozygous for the deletion compared to the insertion polymorphism of the ACE gene. In an attempt to overcome this interaction, we evaluated the short-term renoprotective effect in diabetic nephropathy of the angiotensin II receptor antagonist...

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Share to Angiotensin Receptor Antagonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12081578
DOI: 10.1046/j.1523-1755.2002.00410.x

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Renoprotective effects of losartan in diabetic nephropathy: interaction with ACE insertion/deletion genotype?PMID 12081578Read ↗

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Angiotensin converting enzyme insertion/deletion polymorphism and renoprotection in diabetic and nondiabetic nephropathies.Semantic proximity Read ↗

[The significance of deletion polymorphism in the ACE gene for progression of diabetic nephropathies treated with ACE inhibitors].Semantic proximity Read ↗

Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy.Semantic proximity Read ↗

Deletion insertion polymorphism of the angiotensin converting enzyme gene and progression of diabetic nephropathy.Semantic proximity Read ↗

Angiotensin-converting enzyme (ACE) inhibition in type 2, diabetic patients-- interaction with ACE insertion/deletion polymorphism.Semantic proximity Read ↗

Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control.Semantic proximity Read ↗

Insertion/deletion polymorphism in the angiotensin-I-converting enzyme gene is associated with coronary heart disease in IDDM patients with diabetic nephropathy.Semantic proximity Read ↗

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