Article
Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control.
Diabetologia - 1 Mar 1997
Barnas U, Schmidt A, Illievich A, Kiener H P, Rabensteiner D, Kaider A, Prager R, Abrahamian H, Irsigler K, Mayer G
Abstract excerpt
Diabetic nephropathy represents a major complication in patients with insulin-dependent diabetes mellitus (IDDM). Intervention trials using angiotensin-converting enzyme (ACE) inhibitors have pointed towards the important pathogenetic role of the renin-angiotensin system. Recently an insertion/ deletion (I/D) polymorphism for the gene encoding the ACE has been described, the deletion type being associated with...
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