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Article

Characterization of HCP-6, a C. elegans protein required to prevent chromosome twisting and merotelic attachment.

Genes & development - 15 Jun 2002

Stear Jeffrey H, Roth Mark B

Abstract excerpt

Previous studies of mitosis show that capture of single kinetochores by microtubules from both centrosomes (merotelic orientation) is a major cause of aneuploidy. We have characterized hcp-6, a temperature-sensitive chromosome segregation mutant in C. elegans that exhibits chromosomes attached to both poles via a single sister kinetochore. We demonstrate that the primary defect in this mutant is a failure to...

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Identifiers

PMID: 12080088
DOI: 10.1101/gad.989102
PMCID: PMC186334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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