Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HCP-1, a protein involved in chromosome segregation, is localized to the centromere of mitotic chromosomes in Caenorhabditis elegans.

The Journal of cell biology - 1 Nov 1999

Moore L L, Morrison M, Roth M B

Abstract excerpt

To learn more about holocentric chromosome structure and function, we generated a monoclonal antibody (mAb), 6C4, that recognizes the poleward face of mitotic chromosomes in Caenorhabditis elegans. Early in mitosis, mAb 6C4 stains dots throughout the nucleoplasm. Later in prophase, mAb 6C4 stains structures on opposing faces of chromosomes which orient towards the centrosomes at metaphase. Colocalization with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase
Share to Centromere
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Segregation

Share to Helminth Proteins

Share to Kinetochores

Share to Meiosis

Share to Metaphase

Source

Open in PubMed Open full text

Identifiers

PMID: 10545493
DOI: 10.1083/jcb.147.3.471
PMCID: PMC2151185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HCP-1, a protein involved in chromosome segregation, is localized to the centromere of mitotic chromosomes in Caenorhabditis elegans.PMID 10545493Read ↗

Characterization of HCP-6, a C. elegans protein required to prevent chromosome twisting and merotelic attachment.Semantic proximity Read ↗

A spindle checkpoint functions during mitosis in the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis.Semantic proximity Read ↗

The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli.Semantic proximity Read ↗

Mitch a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila.Semantic proximity Read ↗

Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation.Semantic proximity Read ↗

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.Semantic proximity Read ↗

Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans.Semantic proximity Read ↗

Dissection of CENP-C-directed centromere and kinetochore assembly.Semantic proximity Read ↗

Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans.Semantic proximity Read ↗

Orc mutants arrest in metaphase with abnormally condensed chromosomes.Semantic proximity Read ↗

MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.