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Article

Interaction of Gα 12 with Gα 13 and Gα q signaling pathways

20 Jun 2002

Abstract excerpt

The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the alpha subunit of G(13) die around embryonic day 10 as the result of an angiogenic defect. On the other hand, the physiological role of G(12) is still unclear. To address this issue, we generated G alpha(12)-deficient mice. In...

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PMID: 12077299
DOI: 10.1073/pnas.102291599

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