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Article

Gα12 regulates osteoclastogenesis by modulating NFATc1 expression.

Journal of cellular and molecular medicine - 1 Feb 2018

Song Min-Kyoung, Park Cheolkyu, Lee Yong Deok, Kim Haemin, Kim Min Kyung, Kwon Jun-Oh, Koo Ja Hyun, Joo Min Sung, Kim Sang Geon, Kim Hong-Hee

Abstract excerpt

The G12 family of G protein alpha subunits has been shown to participate in the regulation of various physiological processes. However, the role of Gα12 in bone physiology has not been well described. Here, by micro-CT analysis, we discovered that Gα12-knockout mice have an osteopetrotic phenotype. Histological examination showed lower osteoclast number in femoral tissue of Gα12-knockout mice compared to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, G12-G13

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Source

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Identifiers

PMID: 29077264
DOI: 10.1111/jcmm.13370
PMCID: PMC5783869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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