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Article

G13 controls angiogenesis through regulation of VEGFR-2 expression.

Developmental cell - 28 May 2013

Sivaraj Kishor Kumar, Takefuji Mikito, Schmidt Inga, Adams Ralf H, Offermanns Stefan, Wettschureck Nina

Abstract excerpt

At sites of angiogenesis, the expression of the key angiogenesis regulator vascular endothelial growth factor (VEGF) and its main receptor, VEGF receptor 2 (VEGFR-2), are strongly upregulated. Whereas the processes controlling VEGF expression are well described, the mechanisms underlying VEGFR-2 upregulation have remained unclear. We found that endothelial VEGFR-2 expression is strongly reduced in the absence of...

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PMID: 23664862
DOI: 10.1016/j.devcel.2013.04.008

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