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Article

Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.

The EMBO journal - 3 Aug 1998

Offermanns S, Zhao L P, Gohla A, Sarosi I, Simon M I, Wilkie T M

Abstract excerpt

Heterotrimeric G proteins of the Gq class have been implicated in signaling pathways regulating cardiac growth under physiological and pathological conditions. Knockout mice carrying inactivating mutations in both of the widely expressed G alpha q class genes, G alpha q and G alpha 11, demonstrate that at least two active alleles of these genes are required for extrauterine life. Mice carrying only one intact...

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Identifiers

PMID: 9687499
DOI: 10.1093/emboj/17.15.4304
PMCID: PMC1170764

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