Article
Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.
The EMBO journal - 3 Aug 1998
Offermanns S, Zhao L P, Gohla A, Sarosi I, Simon M I, Wilkie T M
Abstract excerpt
Heterotrimeric G proteins of the Gq class have been implicated in signaling pathways regulating cardiac growth under physiological and pathological conditions. Knockout mice carrying inactivating mutations in both of the widely expressed G alpha q class genes, G alpha q and G alpha 11, demonstrat...
Topics
- Alleles
- Animals
- Animals, Newborn
- Craniofacial Abnormalities
- Crosses, Genetic
- GTP-Binding Proteins
- Gene Dosage
- Heart Defects, Congenital
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Knockout
- Myocardium