Article
Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency.
The Journal of biological chemistry - 2 Oct 2009
Chen Lin, Zhang J Jillian, Rafii Shahin, Huang Xin-Yun
Abstract excerpt
Heterotrimeric G proteins are critical transducers of cellular signaling. Of the four families of G proteins, the physiological function of Galpha(13) is less well understood. Galpha(13) gene-deleted mice die at embryonic day approximately 9.5. Here, we show that heterozygous Galpha(13)(+/-) mice display defects in adult angiogenesis. Female Galpha(13)(+/-) mice showed a higher number of immature follicles and a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.