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Article

Essential role for Galpha13 in endothelial cells during embryonic development.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2005

Ruppel Kathleen M, Willison David, Kataoka Hiroshi, Wang Alice, Zheng Yao-Wu, Cornelissen Ivo, Yin Liya, Xu Shan Mei, Coughlin Shaun R

Abstract excerpt

Toward identifying the roles of protease-activated receptor-1 (PAR1) and other G protein-coupled receptors important for vascular development, we investigated the role of Galpha13 in endothelial cells in the mouse embryo. LacZ inserted into Galpha13 exon 1 was highly expressed in endothelial cells at midgestation. Endothelial-specific Galpha13 knockout embryos died at embryonic days 9.5-11.5 and resembled the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15919816
DOI: 10.1073/pnas.0503326102
PMCID: PMC1149452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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