Article
Mutation analysis of IgVH genes in splenic marginal zone lymphomas: correlation with clinical characteristics and outcome.
Anticancer research - 1 May 2009
Kalpadakis Christina, Pangalis Gerassimos A, Dimitriadou Evangelia, Angelopoulou Maria K, Siakantaris Marina P, Kyrtsonis Marie-Christine, Ximeris Maria, Tzenou Tatiana, Sahanas Sotirios, Yiakoumis Xanthi, Papadaki Eleni A, Panayiotidis Panayiotis, Vassilakopoulos Theodoros
Abstract excerpt
BACKGROUND: To determine the immunoglobulin variable heavy chain (IgVH) gene usage and somatic mutation patterns in a series of SMZL patients and to correlate these findings with the clinical features and outcome. PATIENTS AND METHODS: IgVH genes were amplified and sequenced from 22 SMZL cases. Clinical and laboratory data of these patients were recorded. RESULTS: A biased usage of IgVH gene was found with...
Topics
- Adult
- Aged
- Aged, 80 and over
- Female
- Genes, Immunoglobulin Heavy Chain
- Humans
- Lymphoma
- Male
- Middle Aged
- Mutation
- Splenic Neoplasms
- Treatment Outcome