Article
beta-Catenin alteration in cancer of the ampulla of Vater.
Journal of experimental & clinical cancer research : CR - 1 Mar 2002
Kawakami M, Kimura Y, Furuhata T, Zenbutsu H, Yanai Y, Mukaiya M, Satoh Y, Murata S, Hirata K
Abstract excerpt
To investigate the contribution of beta-catenin to the development of carcinoma of the ampulla of Vater, genetic alterations of beta-catenin gene, CTNNB-1 were searched. Mutational analysis of exon3 in CTNNB-1, which encodes the serine/threonine residues for GSK-3beta phosphorylation sites, was performed on 21 cases of carcinoma of the ampulla of Vater, by means of polymerase chain reaction-single strand...
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