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Article

Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin.

Journal of cutaneous pathology - 1 Feb 2005

Lazar Alexander J F, Calonje Eduardo, Grayson Wayne, Dei Tos Angelo P, Mihm Martin C, Redston Mark, McKee Phillip H

Abstract excerpt

Mutations in beta-catenin are present in benign pilomatrixomas. beta-catenin is a downstream effector in the WNT-signalling pathway, acting as a signal for differentiation and proliferation. Mutations in CTNNB1, the gene encoding beta-catenin, are present in a wide variety of benign and malignant neoplasms. We examined beta-catenin in a series of pilomatrix carcinomas (15 cases) by using immunohistochemistry and...

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Identifiers

PMID: 15606674
DOI: 10.1111/j.0303-6987.2005.00267.x

Genes

CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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