Article
[Mutation analysis of the beta-catenin gene in epithelial carcinomas of the ovaries].
Orvosi hetilap - 21 May 2000
Tanyi J, Páy A, Rigó J, Nagy B, Papp Z
Abstract excerpt
beta-catenin is a continuously expressed cytoplasmic protein that has an important role is both E-cadherin-mediated cell-cell adhesion and in activation of Wnt/Wingless transcriptional pathway. The accumulation of stabilized beta-catenin caused by the mutation of the exon 3 of beta-catenin gene can stimulate the T-cell factor/Lymphoid enhancing factor-mediated transcriptional activation. The activation of...
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