[Gene p53 mutations and overexpression of p53 protein in tumors of the Vater's ampulla].

Abstract excerpt

OBJECTIVES AND METHODS: New prognostic markers for tumors of the ampulla of Vater which could distinguish aggressive lesions would be highly useful. The aim of this study was to evaluate the abnormal expression of p53 protein in a series of 34 ampullomas with the monoclonal antibody DO7 directed against p53 protein. Mutations of exons 5 to 8 of p53 gene were also detected by PCR followed by denaturating gel...

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