Article
Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.
Cell reports - 2 Feb 2016
Gingras Marie-Claude, Covington Kyle R, Chang David K, Donehower Lawrence A, Gill Anthony J, Ittmann Michael M, Creighton Chad J, Johns Amber L, Shinbrot Eve, Dewal Ninad, Fisher William E, Pilarsky Christian, Grützmann Robert, Overman Michael J, Jamieson Nigel B, Van Buren George, Drummond Jennifer, Walker Kimberly, Hampton Oliver A, Xi Liu, Muzny Donna M, Doddapaneni Harsha, Lee Sandra L, Bellair Michelle, Hu Jianhong, Han Yi, Dinh Huyen H, Dahdouli Mike, Samra Jaswinder S, Bailey Peter, Waddell Nicola, Pearson John V, Harliwong Ivon, Wang Huamin, Aust Daniela, Oien Karin A, Hruban Ralph H, Hodges Sally E, McElhany Amy, Saengboonmee Charupong, Duthie Fraser R, Grimmond Sean M, Biankin Andrew V, Wheeler David A, Gibbs Richard A
Abstract excerpt
The ampulla of Vater is a complex cellular environment from which adenocarcinomas arise to form a group of histopathologically heterogenous tumors. To evaluate the molecular features of these tumors, 98 ampullary adenocarcinomas were evaluated and compared to 44 distal bile duct and 18 duodenal adenocarcinomas. Genomic analyses revealed mutations in the WNT signaling pathway among half of the patients and in all...
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