Article
Ampulla of Vater Carcinoma: Sequencing Analysis Identifies TP53 Status as a Novel Independent Prognostic Factor and Potentially Actionable ERBB, PI3K, and WNT Pathways Gene Mutations.
Annals of surgery - 1 Jan 2018
Mafficini Andrea, Amato Eliana, Cataldo Ivana, Rusev Borislav C, Bertoncello Luca, Corbo Vincenzo, Simbolo Michele, Luchini Claudio, Fassan Matteo, Cantù Cinzia, Salvia Roberto, Marchegiani Giovanni, Tortora Giampaolo, Lawlor Rita T, Bassi Claudio, Scarpa Aldo
Abstract excerpt
OBJECTIVE: To identify molecular prognostic factors and potentially actionable mutations in ampulla of Vater cancer (AVC). BACKGROUND: The largely variable outcomes of AVCs make clinical decisions difficult regarding the need of postsurgical therapy, which is based on morphological and immunohistochemical classification that do not adequately consider the varying degrees of heterogeneity present in many AVCs. No...
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