Frequent beta-catenin alteration in gallbladder carcinomas.

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Article

Frequent beta-catenin alteration in gallbladder carcinomas.

Journal of experimental & clinical cancer research : CR - 1 Jun 2003

Kimura Y, Furuhata T, Mukaiya M, Kihara C, Kawakami M, Okita K, Yanai Y, Zenbutsu H, Satoh M, Ichimiya S, Hirata K

Abstract excerpt

To investigate the contribution of beta-catenin to the development of gallbladder carcinoma, genetic alteration in beta-catenin gene, ctnnb-1 and subcellular localization of beta-catenin protein were searched. Mutational analysis of exon 3 in ctnnb-1, which encodes the serine/threonine residues for GSK3beta phosphorylation sites, was performed for 21 gallbladder carcinomas affected with/without the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12866584

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