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Article

RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response.

Genes and immunity - 1 May 2002

Hofmann M A, Drury S, Hudson B I, Gleason M R, Qu W, Lu Y, Lalla E, Chitnis S, Monteiro J, Stickland M H, Bucciarelli L G, Moser B, Moxley G, Itescu S, Grant P J, Gregersen P K, Stern D M, Schmidt A M

Abstract excerpt

The receptor for advanced glycation end products (RAGE) and its proinflammatory S100/calgranulin ligands are enriched in joints of subjects with rheumatoid arthritis (RA) and amplify the immune/inflammatory response. In a model of inflammatory arthritis, blockade of RAGE in mice immunized and challenged with bovine type II collagen suppressed clinical and histologic evidence of arthritis, in parallel with...

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PMID: 12070776
DOI: 10.1038/sj.gene.6363861

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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