Article
A functional p.82G>S polymorphism in the RAGE gene is associated with multiple sclerosis in the Chinese population.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Aug 2011
Li Keshen, Zhao Bin, Dai Dawei, Yao Songpo, Liang Wandong, Yao Lifen, Yang Ze
Abstract excerpt
BACKGROUND: The receptor for advanced glycation end products (RAGE) and its proinflammatory ligand, S100-calgranulins, are critically implicated in the pathological progression of multiple sclerosis (MS). A functional polymorphism within the V-type immunoglobulin domain of RAGE gene, p.82G>S (c.557G>A), has been shown to affect ligand binding affinity and thus may affect susceptibility to MS. METHODS: The RAGE...
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