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Article

Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism

4 Feb 2019

Abstract excerpt

The receptor for advanced glycation end-products (RAGE) is a cell surface transmembrane multiligand receptor, encoded by the AGER gene. RAGE presents many transcripts, is expressed mainly in the lung, and involves multiple pathways (such as NFκB, Akt, p38, and MAP kinases) that initiate and perpetuate an unfavorable proinflammatory state. Due to these numerous functional activities, RAGE is implicated in multiple...

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PMID: 30863465
DOI: 10.1155/2019/2067353

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