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Article

Decreased soluble RAGE in neutrophilic asthma is correlated with disease severity and RAGE G82S variants.

Molecular medicine reports - 1 Mar 2018

Lyu Yanhua, Zhao Haijin, Ye Yanmei, Liu Laiyu, Zhu Shunfang, Xia Yang, Zou Fei, Cai Shaoxi

Abstract excerpt

The advanced glycosylation end product-specific receptor (RAGE) has been demonstrated to be an important mediator of asthma pathogenesis. The soluble isoform of RAGE (sRAGE) acts as a 'decoy' to sequester RAGE ligands, and thus prevents their binding to the receptor. A number of reports have linked deficiency of sRAGE to the severity and outcomes of various human diseases, and association with RAGE G82S variants....

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Identifiers

PMID: 29257350
DOI: 10.3892/mmr.2017.8302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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