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Article

RAGE: therapeutic target and biomarker of the inflammatory response--the evidence mounts.

Journal of leukocyte biology - 1 Sept 2009

Ramasamy Ravichandran, Yan Shi Fang, Schmidt Ann Marie

Abstract excerpt

The RAGE binds multiple ligand families linked to hyperglycemia, aging, inflammation, neurodegeneration, and cancer. Activation of RAGE by its ligands stimulates diverse signaling cascades. The recent observation that the cytoplasmic domain of RAGE interacts with diaphanous or mDia-1 links RAGE signal transduction to cellular migration and activation of the Rho GTPases, cdc42 and rac-1. Pharmacological blockade...

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Identifiers

PMID: 19477910
DOI: 10.1189/jlb.0409230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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