Article
Association of polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating RAGE levels.
The Journal of clinical endocrinology and metabolism - 1 Dec 2009
Gaens Katrien H J, Ferreira Isabel, van der Kallen Carla J H, van Greevenbroek Marleen M J, Blaak Ellen E, Feskens Edith J M, Dekker Jacqueline M, Nijpels Giel, Heine Robert J, 't Hart Leen M, de Groot Philip G, Stehouwer Coen D A, Schalkwijk Casper G
Abstract excerpt
OBJECTIVE: The receptor for advanced glycation end products (RAGE)-ligand interaction has been linked to vascular complications. The family of soluble forms of RAGE (sRAGE) consists of splice variants and proteolytically cleaved and shed forms of RAGE. sRAGE may be a reflection of cell-bound RAGE. Because genetic variation in the RAGE gene may be associated with individual differences in sRAGE concentration and...
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