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Article

Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner.

Developmental biology - 15 Nov 2015

Chen Dongying, Wang Xia, Liang Dong, Gordon Julie, Mittal Ashok, Manley Nancy, Degenhardt Karl, Astrof Sophie

Abstract excerpt

Fibronectin (Fn1) is an evolutionarily conserved extracellular matrix glycoprotein essential for embryonic development. Global deletion of Fn1 leads to mid-gestation lethality from cardiovascular defects. However, severe morphogenetic defects that occur early in embryogenesis in these embryos precluded assigning a direct role for Fn1 in cardiovascular development. We noticed that Fn1 is expressed in strikingly...

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Identifiers

PMID: 26434918
DOI: 10.1016/j.ydbio.2015.09.016
PMCID: PMC5312697

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