Article
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins.
Cell - 13 Nov 1998
Bader B L, Rayburn H, Crowley D, Hynes R O
Abstract excerpt
alphav integrins have been implicated in many developmental processes and are therapeutic targets for inhibition of angiogenesis and osteoporosis. Surprisingly, ablation of the gene for the alphav integrin subunit, eliminating all five alphav integrins, although causing lethality, allows consider...
Topics
- Animals
- Antigens, CD
- Cerebral Hemorrhage
- Chimera
- Embryonic and Fetal Development
- Female
- Gene Expression Regulation, Developmental
- Genes, Lethal
- Homozygote
- Integrin alphaV
- Integrins
- Male
- Mice
- Mice, Congenic
- Mice, Inbred C57BL
- Mutagenesis, Site-Directed
- Mutation
- Neovascularization, Physiologic