Article
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins.
Cell - 13 Nov 1998
Bader B L, Rayburn H, Crowley D, Hynes R O
Abstract excerpt
alphav integrins have been implicated in many developmental processes and are therapeutic targets for inhibition of angiogenesis and osteoporosis. Surprisingly, ablation of the gene for the alphav integrin subunit, eliminating all five alphav integrins, although causing lethality, allows considerable development and organogenesis including, most notably, extensive vasculogenesis and angiogenesis. Eighty percent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.