Article
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins.
Molecular and cellular biology - 1 Nov 2002
McCarty Joseph H, Monahan-Earley Rita A, Brown Lawrence F, Keller Markus, Gerhardt Holger, Rubin Kristofer, Shani Moshe, Dvorak Harold F, Wolburg Hartwig, Bader Bernhard L, Dvorak Ann M, Hynes Richard O
Abstract excerpt
Mouse embryos genetically null for the alphav integrin subunit develop intracerebral hemorrhages at midgestation and die shortly after birth. A key question is whether the hemorrhage arises from primary defects in vascular endothelial cells or pericytes or from other causes. We have previously reported normal initiation of cerebral vessels comprising branched tubes of endothelial cells. Here we show that the...
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