Article
Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development.
Developmental biology - 15 Nov 1999
Yang J T, Bader B L, Kreidberg J A, Ullman-Culleré M, Trevithick J E, Hynes R O
Abstract excerpt
Mouse embryos deficient in fibronectin (FN-null) die at E8.5 with mesodermal defects. Eight integrin heterodimers alpha3beta1, alpha4beta1, alpha5beta1, alpha8beta1, alphavbeta1, alphavbeta3, alphavbeta6, and alphaIIbbeta3 can bind to FN. However, embryos deficient in each of these integrins exhibit less severe defects than do FN-null embryos, raising questions as to which integrin(s) are the key FN receptors for...
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