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Article

HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

25 Aug 2021

Abstract excerpt

Leukemic oncoproteins cause uncontrolled self-renewal of hematopoietic progenitors by aberrant gene activation, eventually causing leukemia. However, the molecular mechanism underlying aberrant gene activation remains elusive. Here, we showed that leukemic MLL fusion proteins associate with the HBO1 histone acetyltransferase (HAT) complex through their trithorax homology domain 2 (THD2) in various human cell...

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PMID: 34431785
DOI: 10.7554/elife.65872

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