Article
Variation in the manganese superoxide dismutase gene (SOD2) is not a major cause of radiotherapy complications in breast cancer patients.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 May 2002
Green Helen, Ross Gillian, Peacock John, Owen Roger, Yarnold John, Houlston Richard
Abstract excerpt
BACKGROUND AND PURPOSE: Small proportions of patients receiving radiotherapy develop marked long-term radiation damage. It is thought that this is due, at least in part, to intrinsic differences in cellular radiosensitivity, but the underlying mechanism is unknown. Reactive oxygen species are involved in cellular radiation damage, hence inter-individual differences in free radical detoxification may be related to...
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