Manganese superoxide dismutase and breast cancer recurrence: a Danish clinical registry-based case-control study, and a meta-analysis.

doi:10.1371/journal.pone.0087450

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Article

Manganese superoxide dismutase and breast cancer recurrence: a Danish clinical registry-based case-control study, and a meta-analysis.

PloS one - 1 Jan 2014

Cronin-Fenton Deirdre P, Christensen Mariann, Lash Timothy L, Ahern Thomas P, Pedersen Lars, Garne Jens Peter, Ewertz Marianne, Autrup Herman, Sørensen Henrik T, Hamilton-Dutoit Stephen

Abstract excerpt

BACKGROUND: Manganese superoxide dismutase (MnSOD) inhibits oxidative damage and cancer therapy effectiveness. A polymorphism in its encoding gene (SOD2: Val16Ala rs4880) may confer poorer breast cancer survival, but data are inconsistent. We examined the association of SOD2 genotype and breast cancer recurrence (BCR) among patients treated with cyclophosphamide-based chemotherapy (Cyclo). We compared our...

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Identifiers

PMID: 24498107
DOI: 10.1371/journal.pone.0087450
PMCID: PMC3909115

Genes

BCR
SOD2

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