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Article

Mutational switch of an IL-6 response to an interferon-γ-like response

11 Jun 2002

Abstract excerpt

Signaling through Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) is central to the responses to the majority of cytokines and some growth factors, including the interferons (IFNs) and the IL-6 family of cytokines. The biological responses to stimulation through the widely distributed IL-6 and IFN-gamma receptors are, however, completely different. Remarkably, it is shown here...

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PMID: 12060750
DOI: 10.1073/pnas.122236099

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