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Article

Stat1-independent regulation of gene expression in response to IFN-γ

5 Jun 2001

Abstract excerpt

Although Stat1 is essential for cells to respond fully to IFN-gamma, there is substantial evidence that, in the absence of Stat1, IFN-gamma can still regulate the expression of some genes, induce an antiviral state and affect cell growth. We have now identified many genes that are regulated by IFN-gamma in serum-starved Stat1-null mouse fibroblasts. The proteins induced by IFN-gamma in Stat1-null cells can...

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PMID: 11390994
DOI: 10.1073/pnas.111164198

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