Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Signaling through a mutant IFN-gamma receptor.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2005

Costa-Pereira Ana P, Hermanns Heike M, Is'harc Hayaatun, Williams Timothy M, Watling Diane, Arulampalam Velmurugesan, Newman Sally J, Heinrich Peter C, Kerr Ian M

Abstract excerpt

Activation of STAT1 and the IFN-gamma response are thought to be mediated exclusively through the Y440 motif of the human IFNGR1 receptor subunit. Contrary to this accepted dogma, here it is shown that IFNGR1 with a mutant (Y440F) motif, when stably expressed in IFNGR1-negative human fibroblasts at levels similar to wild type, can sustain a substantial IFN-gamma response. The mutant receptor supports selective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interferon-gamma
Share to Interferon gamma Receptor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Janus Kinase 1

Share to Phosphatidylinositol 3-Kinases

Share to Protein-Tyrosine Kinases

Share to Receptors, Interferon

Share to STAT1 Transcription Factor

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 16237089
DOI: 10.4049/jimmunol.175.9.5958

Genes

IFNGR1
CIITA
JAK1
STAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signaling through a mutant IFN-gamma receptor.PMID 16237089Read ↗

A conserved IFN-alpha receptor tyrosine motif directs the biological response to type I IFNs.Semantic proximity Read ↗

The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction.Semantic proximity Read ↗

Mutational switch of an IL-6 response to an interferon-γ-like responseSemantic proximity Read ↗

Three patients with defects in interferon gamma receptor signaling: a challenging diagnosisSemantic proximity Read ↗

Impairment of Mycobacterial But Not Viral Immunity by a Germline Human <i>STAT1</i> MutationSemantic proximity Read ↗

Shared receptor components but distinct complexes for alpha and beta interferons.Semantic proximity Read ↗

Stat1-independent regulation of gene expression in response to IFN-γSemantic proximity Read ↗

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.Semantic proximity Read ↗

A novel STAT1 mutation associated with disseminated mycobacterial disease.Semantic proximity Read ↗

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation.Semantic proximity Read ↗

Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiencySemantic proximity Read ↗

Clinically relevant dimer interface mutants of STAT1 transcription factor exhibit differential gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.