Article
Signaling through a mutant IFN-gamma receptor.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2005
Costa-Pereira Ana P, Hermanns Heike M, Is'harc Hayaatun, Williams Timothy M, Watling Diane, Arulampalam Velmurugesan, Newman Sally J, Heinrich Peter C, Kerr Ian M
Abstract excerpt
Activation of STAT1 and the IFN-gamma response are thought to be mediated exclusively through the Y440 motif of the human IFNGR1 receptor subunit. Contrary to this accepted dogma, here it is shown that IFNGR1 with a mutant (Y440F) motif, when stably expressed in IFNGR1-negative human fibroblasts at levels similar to wild type, can sustain a substantial IFN-gamma response. The mutant receptor supports selective...
Topics
- Fibroblasts
- Gene Expression Regulation
- Humans
- Interferon-gamma
- Janus Kinase 1
- Mutation
- Nuclear Proteins
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Protein-Tyrosine Kinases
- Receptors, Interferon
- STAT1 Transcription Factor
- STAT3 Transcription Factor