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Article

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.

Frontiers in immunology - 1 Jan 2018

Michalska Agata, Blaszczyk Katarzyna, Wesoly Joanna, Bluyssen Hans A R

Abstract excerpt

Interferon (IFN)-I and IFN-II both induce IFN-stimulated gene (ISG) expression through Janus kinase (JAK)-dependent phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT2. STAT1 homodimers, known as γ-activated factor (GAF), activate transcription in response to all types of IFNs by direct binding to IFN-II activation site (γ-activated sequence)-containing genes. Association of...

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Identifiers

PMID: 29892288
DOI: 10.3389/fimmu.2018.01135
PMCID: PMC5985295

Genes

STAT2
STAT1

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