IL-6 signal transduction and its physiological roles: the signal orchestration model.

doi:10.1007/s10254-003-0012-2

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Article

IL-6 signal transduction and its physiological roles: the signal orchestration model.

Reviews of physiology, biochemistry and pharmacology - 1 Jan 2003

Kamimura D, Ishihara K, Hirano T

Abstract excerpt

Interleukin (IL)-6 is a pleiotropic cytokine that not only affects the immune system, but also acts in other biological systems and many physiological events in various organs. In a target cell, IL-6 can simultaneously generate functionally distinct or sometimes contradictory signals through its receptor complex, IL-6Ralpha and gp130. One good illustration is derived from the in vitro observations that IL-6...

Topics

Acute-Phase Reaction
Amino Acid Sequence
Animals
Antigens, CD
Autoimmune Diseases
Bone and Bones
Cytokine Receptor gp130
Hematopoiesis
Humans
Interleukin-6
MAP Kinase Signaling System
Membrane Glycoproteins
Models, Immunological
Molecular Sequence Data
Mutation
Neoplasms
Neurosecretory Systems
Phenotype

Source

Open in PubMed

Identifiers

PMID: 12687404
DOI: 10.1007/s10254-003-0012-2

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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