Prolactin Induces SHP-2 Association with Stat5, Nuclear Translocation, and Binding to the β-Casein Gene Promoter in Mammary Cells

doi:10.1074/jbc.m200156200

Article

Prolactin Induces SHP-2 Association with Stat5, Nuclear Translocation, and Binding to the β-Casein Gene Promoter in Mammary Cells

1 Aug 2002

Abstract excerpt

The Src homology 2 (SH2) domain containing protein-tyrosine phosphatase SHP-2 contributes to prolactin receptor (PRLR) signal transduction to beta-casein gene promoter activation. We report for the first time that SHP-2 physically associates with the signal transducer and activator of transcription-5a (Stat5a), an important mediator of PRLR signaling to milk protein gene activation, in the mouse mammary HC11 and...

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