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Article

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling.

Trends in biochemical sciences - 1 Jun 2003

Neel Benjamin G, Gu Haihua, Pao Lily

Abstract excerpt

Src homology-2 (SH2) domain-containing phosphatases (Shps) are a small, highly conserved subfamily of protein-tyrosine phosphatases, members of which are present in both vertebrates and invertebrates. The mechanism of regulation of Shps by ligand binding is now well understood. Much is also known about the normal signaling pathways regulated by each Shp and the consequences of Shp deficiency. Recent studies have...

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Identifiers

PMID: 12826400
DOI: 10.1016/S0968-0004(03)00091-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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