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Article

Shp2 Plays a Critical Role in IL-6-Induced EMT in Breast Cancer Cells.

International journal of molecular sciences - 13 Feb 2017

Sun Xuan, Zhang Jie, Wang Zhiyong, Ji Wei, Tian Ran, Zhang Fei, Niu Ruifang

Abstract excerpt

Accumulative evidence demonstrates that the protein tyrosine phosphatase Shp2 functions as a powerful tumor promoter in many types of cancers. Abnormal expression of Shp2 has been implicated in many human malignancies. Overexpression of Shp2 in cancer tissues is correlated with cancer metastasis, resistance to targeted therapy, and poor prognosis. The well-known function of Shp2 is its positive role in regulating...

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Identifiers

PMID: 28208810
DOI: 10.3390/ijms18020395
PMCID: PMC5343930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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