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Article

SHP-2 regulates SOCS-1-mediated Janus kinase-2 ubiquitination/degradation downstream of the prolactin receptor.

The Journal of biological chemistry - 26 Dec 2003

Ali Samir, Nouhi Zaynab, Chughtai Naila, Ali Suhad

Abstract excerpt

The protein tyrosine phosphatase SHP-2 is an important regulator of the Janus kinase-2 (Jak2)/signal transducer and activator of transcription (Stat) pathway downstream of the cytokine/prolactin receptor family. We report that SHP-2 dephosphorylates tyrosine (Tyr-1007) of Jak2 kinase, a critical...

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Share to Milk Proteins
Share to Oligonucleotides, Antisense
Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Prolactin

Share to STAT5 Transcription Factor

Share to Suppressor of Cytokine Signaling 1 Protein

Share to Suppressor of Cytokine Signaling Proteins

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Source

Identifiers

PMID: 14522994
DOI: 10.1074/jbc.M306758200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14522994-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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