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Article

Quantification of PRL/Stat5 signaling with a novel pGL4-CISH reporter

6 Feb 2008

Abstract excerpt

BACKGROUND: Elevations of serum prolactin (PRL) are associated with an increased risk for breast cancer. PRL signaling through its prolactin receptor (PRLr) involves the Jak2/Stat5 pathway. Luciferase-based reporter assays have been widely used to evaluate the activity of this pathway. However, the existing reporters are often not sensitive enough to monitor the effect of PRL in this pathway. RESULTS: In this...

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PMID: 18254957
DOI: 10.1186/1472-6750-8-11

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