Article

STAT5B SH2 variants disrupt mammary enhancers and the stability of genetic programs during pregnancy

2024-05-09

Abstract excerpt

During pregnancy, mammary tissue undergoes expansion and differentiation, leading to lactation, a process regulated by the hormone prolactin through the JAK2-STAT5 pathway. STAT5 activation is key to successful lactation making the mammary gland an ideal experimental system to investigate the impact of human missense mutations on mammary tissue homeostasis. Here, we investigated the effects of two human variants i...

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Literature Corpus work: af903f5f-6ad0-58cc-b63f-a3ee22a7e8f2
DOI: 10.1101/2024.05.06.592736

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