Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Prolactin/Prolactin Receptor Signaling in Human Breast Cancer

1 Dec 2003

Abstract excerpt

Prolactin (PRL), a hormone utilized at both the endocrine and autocrine levels, stimulates breast epithelial growth, differentiation, and motility. Recent data at the cellular, epidemiologic, and genetic levels have implicated a significant role for this hormone in the pathogenesis of human breast cancer. A family of prolactin receptor (PRLr) isoforms mediates the effects of PRL in human tissue. Now numbering...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Estrogen and related hormone effects
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15687690
DOI: 10.3233/bd-2003-18108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Prolactin/Prolactin Receptor Signaling in Human Breast CancerPMID 15687690Read ↗

The Role of Prolactin in Mammary CarcinomaSemantic proximity Read ↗

Breast Cancer and Prolactin – New Mechanisms and ModelsSemantic proximity Read ↗

Prolactin receptor gene transcriptional control, regulatory modalities relevant to breast cancer resistance and invasivenessSemantic proximity Read ↗

The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer.Semantic proximity Read ↗

Quantification of PRL/Stat5 signaling with a novel pGL4-CISH reporterSemantic proximity Read ↗

Prolactin Pro-Differentiation Pathway in Triple Negative Breast Cancer: Impact on Prognosis and Potential TherapySemantic proximity Read ↗

Role of c-Myb during Prolactin-Induced Signal Transducer and Activator of Transcription 5a Signaling in Breast Cancer CellsSemantic proximity Read ↗

A favorable role of prolactin in human breast cancer reveals novel pathway-based gene signatures indicative of tumor differentiation and favorable patient outcome.Semantic proximity Read ↗

Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.Semantic proximity Read ↗

Growth Hormone Signaling in Human T47D Breast Cancer Cells: Potential Role for a Growth Hormone Receptor-Prolactin Receptor ComplexSemantic proximity Read ↗

Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins.Semantic proximity Read ↗

The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.